• Posted 12/19/2024.
    =====================

    I am still waiting on my developer to finish up on the Classifieds Control Panel so I can use it to encourage members into becoming paying members. Google Adsense has become a real burden on the viewing of this site, but honestly it is the ONLY source of income now that keeps it afloat. I tried offering disabling the ads being viewed by paying members, but apparently that is not enough incentive. Quite frankly, Google Adsense has dropped down to where it barely brings in enough daily to match even a single paid member per day. But it still gets the bills paid. But at what cost?

    So even without the classifieds control panel being complete, I believe I am going to have to disable those Google ads completely and likely disable some options here that have been free since going to the new platform. Like classified ad bumping, member name changes, and anything else I can use to encourage this site to be supported by the members instead of the Google Adsense ads.

    But there is risk involved. I will not pay out of pocket for very long during this last ditch experimental effort. If I find that the membership does not want to support this site with memberships, then I cannot support your being able to post your classified ads here for free. No, I am not intending to start charging for your posting ads here. I will just shut the site down and that will be it. I will be done with FaunaClassifieds. I certainly don't need this, and can live the rest of my life just fine without it. If I see that no one else really wants it to survive neither, then so be it. It goes away and you all can just go elsewhere to advertise your animals and merchandise.

    Not sure when this will take place, and I don't intend to give any further warning concerning the disabling of the Google Adsense. Just as there probably won't be any warning if I decide to close down this site. You will just come here and there will be some sort of message that the site is gone, and you have a nice day.

    I have been trying to make a go of this site for a very long time. And quite frankly, I am just tired of trying. I had hoped that enough people would be willing to help me help you all have a free outlet to offer your stuff for sale. But every year I see less and less people coming to this site, much less supporting it financially. That is fine. I tried. I retired the SerpenCo business about 14 years ago, so retiring out of this business completely is not that big if a step for me, nor will it be especially painful to do. When I was in Thailand, I did not check in here for three weeks. I didn't miss it even a little bit. So if you all want it to remain, it will be in your hands. I really don't care either way.

    =====================
    Some people have indicated that finding the method to contribute is rather difficult. And I have to admit, that it is not all that obvious. So to help, here is a thread to help as a quide. How to become a contributing member of FaunaClassifieds.

    And for the record, I will be shutting down the Google Adsense ads on January 1, 2025.
  • Responding to email notices you receive.
    **************************************************
    In short, DON'T! Email notices are to ONLY alert you of a reply to your private message or your ad on this site. Replying to the email just wastes your time as it goes NOWHERE, and probably pisses off the person you thought you replied to when they think you just ignored them. So instead of complaining to me about your messages not being replied to from this site via email, please READ that email notice that plainly states what you need to do in order to reply to who you are trying to converse with.

Global Snakebite Envenomation and Antivenin Report

M

Martin Nowak

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"Exact numbers can be hard to determine, but globally it’s estimated that as many as 2.7 million people are envenomed by snakes every year. Of these, up to 400,000 are permanently disabled, and estimates suggest that 81,000 to 138,000 die. Poorer nations suffer the greatest proportion of snake bites."

"The world produces less antivenom than it needs, and production quality varies. The cost to manufacture the remedy is more than most patients can afford, and anti-venom isn’t exactly a profitable business, which deters its production. And those bitten often live in remote areas where they can't access antivenom quickly."

"Development is underway for a universal snake antivenom"
Quotes Source: "Today in Science - Scientific American". 9/27/2023

Full Report:
https://www.scientificamerican.com/...tes-each-year-than-have-ever-died-from-ebola/
 
I would assume a synthetic antivenin would cost more than the real thing to manufacture. And I don't understand how you could have a "universal" antivenin? So many enzymes in each of the different types of venom, that would be a tough endeavor.
 
It would seem a tall order and complex undertaking to develop a synthetic universal antivenin. Even if one considered broad groupings such as "universal elapid" or "universal crotalid" and so forth. There are reports of successful bite treatment when species specific antivenin is unavailable but "closely related" species antivenin is available and used. I recall this among elapid envenomations.
It has been known for some years that CroFab is less effective on bites from C. helleri and C. oreganus. I don't know if these species' venom is used in production - suspect not. Here is a recent report (December 2022) indicating CroFab was not effective in treating a patient with C. helleri envenomation. Readers may also wish to look at the citations at the end of the article. Multiple reports of "how well CroFab worked on different species".
https://www.sciencedirect.com/science/article/abs/pii/S0196064422004401
 
Several years ago I was engaged to write a business plan for a VC start-up coral snake antivenin production facility. It quickly became apparent that such is enormously expensive for extremely few incidences and the notion was terminated. Plus, coral snake envenomation can be treated without antivenin.

Here is the Ophirex-BRAVO updated clinical trial link. Note that the Phase 2 trial reports completion in June 2023 with 96 of desired 110 participants. Will be interesting to read their results when available.
https://clinicaltrials.gov/study/NCT04996264

Here is the home page for Ophirex:
https://www.ophirex.com/


Here is the January 2023 Series B funding round of $37 million:
https://www.ophirex.com/20230105-ophirex-completes-37-million-series-b-financing
 
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